BackgroundThe biopharmaceutical industry operates at the intersection of life sciences, clinical research, clinical care, public health, and business, which presents distinct operational and ethical challenges. This setting merits focused bioethics consideration to complement legal compliance and business ethics efforts. However, bioethics as applied to a biopharmaceutical industry setting often is construed either too broadly or too narrowly with little examination of its proper scope.Main textAny institution with a scientific or healthcare mission should engage bioethics norms to navigate ethical issues that (...) arise from the conduct of biomedical research, delivery of clinical care, or implementation of public health programs. It is reasonable to assume that while bioethics norms must remain constant, their application will vary depending on the characteristics of a given setting. Context “specification” substantively refines ethics norms for a particular discipline or setting and is an expected, needed and progressive ethical activity. In order for this activity to be meaningful, the scope for bioethics application and the relevant contextual factors of the setting need to be delineated and appreciated. This paper defines biopharmaceutical bioethics as: the application of bioethics norms (concepts, principles, and rules) to the research, development, supply, commercialization, and clinical use of biopharmaceutical healthcare products. It provides commentary on this definition, and presents five contextual factors that need to be considered when applying bioethics norms to a biopharmaceutical industry setting: (1) dual missions; (2) timely and pragmatic guidance; (3) resource stewardship; (4) multiple stakeholders; and (5) operational complexity.ConclusionUnderstanding the scope of the biopharmaceutical enterprise and contextual factors of a biopharmaceutical industry setting is foundational for the application of bioethics norms. Establishing a common language and approach for biopharmaceutical bioethics will facilitate breadth and depth of discussion and subsequent implementation to benefit patients, the healthcare system and society. (shrink)

Background: Bioethics consultations are conducted in varied settings, including hospitals, universities, and other research institutions, but there is sparse information about bioethics consultations conducted in corporate settings such as pharmaceutical companies. The purpose of this article is to describe a bioethics consultation service at a pharmaceutical company, to report characteristics of consultations completed by the service over a 6-year period, and to share results of a consultation feedback survey. Methods: Data on the descriptive characteristics of bioethics consultations were collected from (...) 2008 to 2013 and analyzed in Excel 2007. Categorical data were analyzed via the pivot table function, and time-based variables were analyzed via formulas. The feedback survey was administered to consultation requesters from 2009 to 2012 and also analyzed in Excel 2007. Results: Over the 6-year period, 189 bioethics consultations were conducted. The number of consultations increased from five per year in 2008 to approximately one per week in 2013. During this time, the format of the consultation service was changed from a committee-only approach to a tiered approach (tailored to the needs of the case). The five most frequent topics were informed consent, early termination of a clinical trial, benefits and risks, human biological samples, and patient rights. The feedback survey results suggest the consultation service is well regarded overall and viewed as approachable, helpful, and responsive. Conclusions: Pharmaceutical bioethics consultation is a unique category of bioethics consultation that primarily focuses on pharmaceutical research and development but also touches on aspects of clinical ethics, business ethics, and organizational ethics. Results indicate there is a demand for a tiered bioethics consultation service within this pharmaceutical company and that advice was valued. This company's experience indicates that a bioethics consultation service raises awareness about bioethics, empowers employees to raise bioethical concerns, and helps them reason through challenging issues. (shrink)

It is not uncommon to be frustrated by the outcome of an election or a decision in voting, law, economics, engineering, and other fields. Does this 'bad' result reflect poor data or poorly informed voters? Or does the disturbing conclusion reflect the choice of the decision/election procedure? Nobel Laureate Kenneth Arrow's famed theorem has been interpreted to mean 'no decision procedure is without flaws'. Similarly, Nobel Laureate Amartya Sen dashes hope for individual liberties by showing their incompatibility with societal needs. (...) This highly accessible book offers a new, different interpretation and resolution of Arrow's and Sen's theorems. Using simple mathematics, it shows that these negative conclusions arise because, in each case, some of their assumptions negate other crucial assumptions. Once this is understood, not only do the conclusions become expected, but a wide class of other phenomena can also be anticipated. (shrink)

Claims that representatives of both sides of the psi debate (e.g., J. E. Alcock; K. R. Rao and J. Palmer [see PA, Vol 76:10501 and 10507]) have implicitly adopted the empirical epistemology without spelling out or systematically applying the rational epistemology, an essential step for both psychology and parapsychology. ((c) 1997 APA/PsycINFO, all rights reserved).

The concept of “the good life” is not one that receives much attention from conventional economic theory.1 About the closest it comes to such attention is in the area of welfare economics and here it is mostly concerned with the distribution of costs and benefits of various economic choices and wherein benefits are measured in terms of utility and costs in terms of disutility or utility foregone. It is usually taken for granted that utility is a function of consumption of (...) goods and services, and disutility is a function of the “toil and trouble” associated with the effort to acquire goods and services. Labor, therefore, is typically taken to be a major source of disutility. Even many economists will admit that .. (shrink)

It is well known that decision methods based on pairwise rankings can suffer from a wide range of difficulties. These problems are addressed here by treating the methods as systems, where each pair is looked upon as a subsystem with an assigned task. In this manner, the source of several difficulties is equated with the standard concern that the “whole need not be the sum of its parts.” These problems arise because the objectives assigned to subsystems need not be compatible (...) with that of the system. Knowing what causes the difficulties leads to resolutions. (shrink)

This paper examines how inner theories influence lexical choice. Subjects in one study completed auditorily presented sentence fragments, some of which contained nonhuman antecedents such as dog and cat. Subjects were more likely to use human pronouns rather than it for referring to pets rather than nonpets , and antecedents that were liked rather than disliked , familiar rather than unfamiliar , named rather than unnamed , rational rather than nonrational , and engaging in typically human rather than nonhuman activities (...) . The beliefs and attitudes underlying these pronoun choices intruded not just hypoconsciously , but contraconsciously . A second study examined rapidly generated inferences that influenced what pronoun subjects chose to complete visually presented sentences, such as "When a student practices basketball instead of studying" and "When a student practices ballet instead of studying." The results indicated that inferences from beliefs altered the choice of pronoun from predominately he to predominantly she. Other results indicated that pronouns have semi-autonomous functions of their own, and reflect beliefs and attitudes that vary with subject sex, and are context dependent, pragmatic in nature, and dynamic over time. (shrink)

Grafts of embryonic neural tissue into the brains of adult patients are currently being used to treat Parkinson's disease and are under serious consideration as therapy for a variety of other degenerative and traumatic disorders. This target article evaluates the use of transplants to promote recovery from brain injury and highlights the kinds of questions and problems that must be addressed before this form of therapy is routinely applied. It has been argued that neural transplantation can promote functional recovery through (...) the replacement of damaged nerve cells, the reestablishment of specific nerve pathways lost as a result of injury, the release of specific neurotransmitters, or the production of factors that promote neuronal growth. The latter two mechanisms, which need not rely on anatomical connections to the host brain, are open to examination for nonsurgical, less intrusive therapeutic use. Certain subjective judgments used to select patients who will receive grafts and in assessment of the outcome of graft therapy make it difficult to evaluate the procedure. In addition, little long-term assessment of transplant efficacy and effect has been done in nonhuman primates. Carefully controlled human studies, with multiple testing paradigms, are also needed to establish the efficacy of transplant therapy. (shrink)

This chapter examines the stages of processing meta‐theory (SPM) that has guided construction of theories in psychology during the past 350 years, from philosopher René Descartes in seventeenth‐century France to neuropsychologists Carl Wernicke and Paul Broca in nineteenth‐century Europe to psychologists Dominic Massaro and Alan Baddeley in late twentieth‐century America and Britain. The most basic SPM assumptions are that processing and storage of information take place within a finite number of autonomous modules or stages, and that some stages are sequentially (...) ordered with respect to others. Flowcharts typically summarize these assumptions. The traditional stages of processing for verbal information are comprehension, storage, retrieval, and production. SPM flowcharts can add new stages and can alter old labels to represent new types of information processing, but whatever the labels, the stages must be finite in number, distinct, independent, and sequentially ordered between input and output. (shrink)

Frank Tipler's The Physics of Immortality provides abundant cause for intellectual offense—including challenges to physics, to theology, and, seemingly, to common sense. Few philosophical conundrums remain unaddressed. Still, the book is stimulating and well presented.

Each entry includes a brief listing of the subjects covered in the work. The volume also includes a full subject index and an author index.

In lieu of an abstract, here is a brief excerpt of the content:The Gospel of Mark: A Mahayana ReadingDonald G. LuckThe Gospel of Mark: A Mahayana Reading. By John P. Keenan. Maryknoll, NY: Orbis Books, 1995.This is the latest effort of society member John Keenan to “pass over” (as John Dunne puts it) from one tradition to another in order to return to one’s point of departure with fresh perspective and heightened awareness. This book reflects impressive scholarship and builds on (...) the theological indebtedness to Madhyamika [End Page 210] and Yogacara thought that shaped Keenan’s earlier work, The Meaning of Christ: A Mahayana Theology, also published by Orbis. The noses of academic purists may be put out of joint by what some might construe as a blurring of boundaries between Buddhism and Christianity, but Keenan places himself right in the thick of current hermeneutical discussions to establish the fruitfulness of Mahayana perspective in interpreting the “charter document of the Christian Gospel” (p. 4). He finds methodological legitimization both in the arguments of narrative criticism and in the lines of connection he discerns between deconstruction and the Mahayana recognition of emptiness. And in so arguing, he finds himself able to account for forms of New Testament criticism such as those advanced by John Dominic Crossan and Werner Kelber that not only undermine forms of essentialism but also resort to conventional modes of thinking and discourse without justifying the latter.What is unwittingly going on, argues Keenan, is parallel to the Mahayana identification of emptiness (shunyata) with dependent co-arising (pratitya samutpada). Like deconstructionist hermenuetics, emptiness destablizes all fixed views by recognizing that ultimate truth is ineffable and silent. However, unlike deconstruction, emptiness avoids the vertigo of a text lost in the interplay of interpretations doubling back on themselves. “That is emptiness ineptly apprehended as itself an essentialist viewpoint that there are no viewpoints” (p. 7). Instead, Mahayana analysis connects recognition of the total otherness of ultimate meaning with the affirmation of worldly convention in its limitation. The result is a hermeneutic of nonabsolutizing suggestiveness shaped by upaya, which leads the reader to the possibility of enlightenment —or, in the case of Mark, disclosure.According to Keenan, this Mahayana recognition of the identity of emptiness and dependent co-arising not only has hermeneutical legitimation but also is the key for unlocking a fresh appreciation of Mark’s contents. Accounting for this is the fact that “the Marcan rhetoric of indirection and irony is the narrative analogue to the Madhyamika dialectical rhetoric employed in Nagarjuna’s Stanzas on the Middle” and the fact that “Mahayana eschews precisely those clarifying elements that Matthew and Luke have added to domesticate Mark’s story and discourse, preferring the opacity of ultimate meaning to the full explication of stated truths, opting for the emptying of all themes and ideas in order to reclaim them with an awakened mind” (p. 4).Keenan’s approach is coherent with Crossan’s observation that while mythos creates a universe of meaning, parable undermines established cosmoi. In this respect, Jesus not only speaks parable, he is parable. Utilizing the Mahayana identification of emptiness with dependent co-arising as a heuristic device and paying close attention to the Greek text, Keenan traces the simultaneously destablizing and restorative effect that Jesus has on his hearers—and that the evangelist potentially can have on his readers. Jesus’ “desert spirituality,” that is, his radically unconventional vision, undermines the expectations and securities of both hearer and reader. But it also reconnects those effected by the liberation he works “not to the ultimate glory of a false kingdom imagined by the disciples and the readers, but to the conventional realm of human living in which alone the kingdom may be established” (p. 73; italics added). Indeed, Jesus’ crucifixion makes clear that the transformation wrought [End Page 211] by the Gospel is an existential reappropriation of ordinary life in the face of ultimate mystery, not some supernatural deliverance within or from it. Appropriately, Mark ends with the women being confronted by both the jarring and ineffable mystery of Jesus’ empty tomb and the promise that he will see the disciples again in the familiar—and open-ended—context of life in Galilee.Keenan has done more... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Buddhist-Christian Studies 20 (2000) 282-287 [Access article in PDF] Book Review Wrestling with the Ox: A Theology of Religious Experience Wrestling with the Ox: A Theology of Religious Experience. By Paul O. Ingram. New York: Continuum, 1997. 276 pp. Paul Ingram has set out a formidable task for himself. Even though he identifies himself as an historian of religion, he has chosen to push beyond phenomenological description of the (...) religious enterprise to make a prescriptive proposal, a theology that can illuminate and guide the great faith traditions. Simultaneously, his proposal aims at interpreting the necessity and the outlines of interreligious dialogue. Such dialogue, he argues, is not a peripheral enterprise reserved for a handful of religious exotics. It is central to understanding any and all religious traditions in the postmodern world.All religions have been discovered to reflect inescapable historical and cultural relativization. The old assumptions of unconditional claims and absolute assertions are no longer tenable. The world shared by all the religions today is characterized by an unavoidable religious pluralism. It is in this context that religious affirmations must be expressed and religious life embraced. According to Ingram, this is no accident. It is an ontological inevitability. As process philosophy and its roots in modern physics [End Page 282] --and, interestingly, the Buddhist recognition of dependent co-arising (pratitya samutpada)--understand, reality is unending process. This entails the inevitable relativization and contextualization of everything--including the religions. The theological questions that emerge are crucial ones. Among them: Is there an ultimate unity underlying this diversity, generic features common to all conditioned forms of religious faith and practice? What does religious pluralism show about the nature of the Sacred and of being human? Is any one religious Way best or is this even a question worth pursuing?Ingram proposes that the answers to these questions and the only viable response to religious pluralism can be found in interreligious dialogue. He does not even consider religious exclusivism as a viable option. This means only "inclusivist" and "pluralist" approaches are worthy of consideration, approaches that he names the "theology-of-religions model" and the "primordial model" respectively. Both recognize the problem of the relativity of belief and seek to overcome it. Both see the importance of interreligious dialogue as fundamental to religious affirmation. But Ingram rejects the theology-of-religions model because, despite its openness to other religions and its willingness to have interreligious encounter shape the affirmations and life of the believing community, it is self-encapsulated. One moves out from a particular community of faith, "passing over"--to use the language of John Dunne--into another religious Way in order to be creatively transformed, but only to return once again to the original community of faith. One stays within "the theological circle" (Tillich), one does not get beyond it. Some Christians, accordingly, make a blanket assertion about the ultimate and unsurpassable lordship of Christ despite their indebtedness to the creative transformation that interreligious dialogue can produce.Ingram clearly prefers the "primordial model" even though he recognizes that some of its classical proponents have made it vulnerable to criticism. Aldous Huxley's "perennial philosophy" and Sri Ramakrishan's assertion that "all paths lead to the summit" will not do. Huxley assumes that the mystical recognition of the ineffable common root of all religion critiques the historical and culturally relative expressions of this ultimate reality. But Huxley's attempt to make an end run around the problems involved won't work. His approach is ahistorical, makes uncritical assumptions about the nature of mysticism and religious experience, and is totally undialogical. The particularities of the differing religious Ways are dissolved in a universal solvent that is anything but self-evident. The same holds true for Ramakrishnan's subtly imperialistic (and very Hindu) model. It too has no room for religious particularity and imposes a pre-conceived common denominator on the multiplicity of religious phenomena.Ingram derives his term "primordial model" from Huston Smith's argument that a "primordial tradition" can be discerned underlying the multiplicity and variety of religious expressions. His is... (shrink)

As we conceived of Interpretation, we had no interest in merely launching another journal; in providing another channel of literary expression; or in creating another public relations medium for the purpose of making Union Theological Seminary more widely known. No, we designed Interpretation to have a mission. Our aim was to create a medium through which the church would understand more fully its nature as the body of Christ giving expression to the will of its head.